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  "Title": "Target Controlled Infusion (TCI)",
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  "Description": "Implementation of target-controlled infusion algorithms\nfor compartmental pharmacokinetic and\npharmacokinetic-pharmacodynamic models. Jacobs (1990)\n<doi:10.1109/10.43622>; Marsh et al. (1991)\n<doi:10.1093/bja/67.1.41>; Shafer and Gregg (1993)\n<doi:10.1007/BF01070999>; Schnider et al. (1998)\n<doi:10.1097/00000542-199805000-00006>; Abuhelwa, Foster, and\nUpton (2015) <doi:10.1016/j.vascn.2015.03.004>; Eleveld et al.\n(2018) <doi:10.1016/j.bja.2018.01.018>.",
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    "assign_pars",
    "bayes_update",
    "clc",
    "elvdlpars",
    "emax",
    "emax_eleveld",
    "emax_inv",
    "emax_inv_eleveld",
    "emax_inv_remi",
    "emax_remi",
    "format_pars",
    "inf_manual",
    "inf_tci",
    "inf_tci_pop",
    "infer_pkfn",
    "init_pkmod",
    "init_poppkmod",
    "list_parnms",
    "list_pkmods",
    "log_likelihood",
    "log_posterior_neg",
    "log_prior",
    "olc",
    "pkmod",
    "pkmod_eleveld_ppf",
    "pkmod_eleveld_remi",
    "pkmod_kim",
    "pkmod_marsh",
    "pkmod_minto",
    "pkmod_schnider",
    "pkmod1cpt",
    "pkmod2cpt",
    "pkmod3cpt",
    "pkmod3cptm",
    "poppkmod",
    "sample_iiv",
    "sample_pkmod",
    "simulate_clc",
    "simulate_olc",
    "simulate_tci",
    "tci_effect",
    "tci_effect_only",
    "tci_plasma",
    "validate_pkmod",
    "validate_poppkmod"
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      "title": "Eleveld et al. pharmacodynamic data",
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      "class": [
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      ],
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        "E50",
        "KE0",
        "EMAX",
        "GAM",
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        "RESD",
        "ALAG1",
        "AGE",
        "WGT",
        "HGT",
        "M1F2",
        "A1V2",
        "PMA",
        "TECH"
      ],
      "rows": 122,
      "table": true,
      "tojson": true
    },
    {
      "name": "eleveld_pk",
      "title": "Eleveld et al. pharmacokinetic data",
      "object": "eleveld_pk",
      "class": [
        "data.frame"
      ],
      "fields": [
        "ID",
        "V1",
        "V2",
        "V3",
        "CL",
        "Q2",
        "Q3",
        "AGE",
        "WGT",
        "HGT",
        "M1F2",
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        "TECH",
        "BMI",
        "FFM",
        "A1V2"
      ],
      "rows": 1033,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "apply_tci",
      "title": "Apply a TCI algorithm to a `pkmod` object",
      "topics": [
        "apply_tci"
      ]
    },
    {
      "page": "assign_pars",
      "title": "Set default PK parameter values Set default PK parameter values for a pkmod object.",
      "topics": [
        "assign_pars"
      ]
    },
    {
      "page": "bayes_update",
      "title": "Update PK-PD model parameters using observed data values",
      "topics": [
        "bayes_update"
      ]
    },
    {
      "page": "clc",
      "title": "Simulate closed-loop control",
      "topics": [
        "clc"
      ]
    },
    {
      "page": "eleveld_pd",
      "title": "Eleveld et al. pharmacodynamic data",
      "topics": [
        "eleveld_pd"
      ]
    },
    {
      "page": "eleveld_pk",
      "title": "Eleveld et al. pharmacokinetic data",
      "topics": [
        "eleveld_pk"
      ]
    },
    {
      "page": "elvdlpars",
      "title": "Get logged parameters updated in Eleveld model",
      "topics": [
        "elvdlpars"
      ]
    },
    {
      "page": "emax",
      "title": "Emax function",
      "topics": [
        "emax"
      ]
    },
    {
      "page": "emax_eleveld",
      "title": "Emax function for Eleveld (2018) model.",
      "topics": [
        "emax_eleveld"
      ]
    },
    {
      "page": "emax_inv",
      "title": "Inverse Emax function",
      "topics": [
        "emax_inv"
      ]
    },
    {
      "page": "emax_inv_eleveld",
      "title": "Inverse Emax function",
      "topics": [
        "emax_inv_eleveld"
      ]
    },
    {
      "page": "emax_inv_remi",
      "title": "Inverse Emax function implemented by Eleveld remifentanil model",
      "topics": [
        "emax_inv_remi"
      ]
    },
    {
      "page": "emax_remi",
      "title": "Emax function implemented by Eleveld remifentanil model",
      "topics": [
        "emax_remi"
      ]
    },
    {
      "page": "format_pars",
      "title": "Format parameters for use in Rcpp functions",
      "topics": [
        "format_pars"
      ]
    },
    {
      "page": "inf_manual",
      "title": "infusion schedule",
      "topics": [
        "inf_manual"
      ]
    },
    {
      "page": "inf_tci",
      "title": "Target-controlled infusion",
      "topics": [
        "inf_tci"
      ]
    },
    {
      "page": "inf_tci_pop",
      "title": "Calculate infusion rates to reach target values within a population",
      "topics": [
        "inf_tci_pop"
      ]
    },
    {
      "page": "infer_pkfn",
      "title": "Identify pkfn from parameter names",
      "topics": [
        "infer_pkfn"
      ]
    },
    {
      "page": "init_pkmod",
      "title": "Create an object with class \"pkmod\"",
      "topics": [
        "init_pkmod"
      ]
    },
    {
      "page": "init_poppkmod",
      "title": "Initialize a `poppkmod` object.",
      "topics": [
        "init_poppkmod"
      ]
    },
    {
      "page": "list_parnms",
      "title": "Identify pkfn from parameter names",
      "topics": [
        "list_parnms"
      ]
    },
    {
      "page": "list_pkmods",
      "title": "Print population PK models available in `tci`",
      "topics": [
        "list_pkmods"
      ]
    },
    {
      "page": "log_likelihood",
      "title": "Evaluate the log likelihood of a vector of parameter values",
      "topics": [
        "log_likelihood"
      ]
    },
    {
      "page": "log_posterior_neg",
      "title": "Evaluate the negative log posterior value of a parameter vector",
      "topics": [
        "log_posterior_neg"
      ]
    },
    {
      "page": "log_prior",
      "title": "Calculate logged-prior probability for a set of parameters",
      "topics": [
        "log_prior"
      ]
    },
    {
      "page": "olc",
      "title": "Simulate open-loop control",
      "topics": [
        "olc"
      ]
    },
    {
      "page": "pkmod",
      "title": "Create a pkmod object",
      "topics": [
        "pkmod"
      ]
    },
    {
      "page": "pkmod_eleveld_ppf",
      "title": "Eleveld population PK model for propofol",
      "topics": [
        "pkmod_eleveld_ppf"
      ]
    },
    {
      "page": "pkmod_eleveld_remi",
      "title": "Eleveld population PK model for remifentanil",
      "topics": [
        "pkmod_eleveld_remi"
      ]
    },
    {
      "page": "pkmod_kim",
      "title": "Kim population PK model for remifentanil",
      "topics": [
        "pkmod_kim"
      ]
    },
    {
      "page": "pkmod_marsh",
      "title": "-------------------------- Population PK and PK-PD functions --------------- -------------------------- Marsh population PK model for propofol",
      "topics": [
        "pkmod_marsh"
      ]
    },
    {
      "page": "pkmod_minto",
      "title": "Minto population PK model for remifentanil",
      "topics": [
        "pkmod_minto"
      ]
    },
    {
      "page": "pkmod_schnider",
      "title": "Schnider population PK model for propofol",
      "topics": [
        "pkmod_schnider"
      ]
    },
    {
      "page": "pkmod1cpt",
      "title": "One compartment IV infusion with first-order elimination.",
      "topics": [
        "pkmod1cpt"
      ]
    },
    {
      "page": "pkmod2cpt",
      "title": "Two compartment IV infusion with first-order elimination.",
      "topics": [
        "pkmod2cpt"
      ]
    },
    {
      "page": "pkmod3cpt",
      "title": "Three compartment IV infusion with first-order elimination.",
      "topics": [
        "pkmod3cpt"
      ]
    },
    {
      "page": "pkmod3cptm",
      "title": "Solution to three-compartment IV model with effect-site",
      "topics": [
        "pkmod3cptm"
      ]
    },
    {
      "page": "plot.sim_tci",
      "title": "Plot method for sim_tci class",
      "topics": [
        "plot.sim_tci"
      ]
    },
    {
      "page": "poppkmod",
      "title": "Implement a population pharmacokinetic/pharmacodynamic model.",
      "topics": [
        "poppkmod"
      ]
    },
    {
      "page": "predict.pkmod",
      "title": "Predict method for pkmod objects",
      "topics": [
        "predict.pkmod"
      ]
    },
    {
      "page": "predict.poppkmod",
      "title": "Predict method for pkmod objects",
      "topics": [
        "predict.poppkmod"
      ]
    },
    {
      "page": "print.pkmod",
      "title": "Print pkmod",
      "topics": [
        "print.pkmod"
      ]
    },
    {
      "page": "print.poppkmod",
      "title": "Print poppkmod",
      "topics": [
        "print.poppkmod"
      ]
    },
    {
      "page": "print.sim_tci",
      "title": "Print method for sim_tci class",
      "topics": [
        "print.sim_tci"
      ]
    },
    {
      "page": "sample_iiv",
      "title": "Sample PK or PK-PD parameters from the distribution of inter- or intra-individual variability",
      "topics": [
        "sample_iiv"
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    },
    {
      "page": "sample_pkmod",
      "title": "Sample parameters from a `pkmod` object",
      "topics": [
        "sample_pkmod"
      ]
    },
    {
      "page": "simulate_clc",
      "title": "Simulate closed-loop control using Bayesian updates",
      "topics": [
        "simulate_clc"
      ]
    },
    {
      "page": "simulate_olc",
      "title": "Simulate open-loop control using TCI",
      "topics": [
        "simulate_olc"
      ]
    },
    {
      "page": "simulate_tci",
      "title": "Simulate open- or closed-loop control",
      "topics": [
        "simulate_tci"
      ]
    },
    {
      "page": "simulate.pkmod",
      "title": "Simulate method for pkmod objects",
      "topics": [
        "simulate.pkmod"
      ]
    },
    {
      "page": "simulate.poppkmod",
      "title": "Summary method for `poppkmod` objects",
      "topics": [
        "simulate.poppkmod"
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    {
      "page": "tci_documentation",
      "title": "tci_documentation",
      "topics": [
        "tci_documentation"
      ]
    },
    {
      "page": "tci_effect",
      "title": "Effect-site TCI algorithm with plasma targeting within small range of target",
      "topics": [
        "tci_effect"
      ]
    },
    {
      "page": "tci_effect_only",
      "title": "TCI algorithm for effect-site targeting",
      "topics": [
        "tci_effect_only"
      ]
    },
    {
      "page": "tci_plasma",
      "title": "TCI algorithm for plasma targeting",
      "topics": [
        "tci_plasma"
      ]
    },
    {
      "page": "update.pkmod",
      "title": "Update method for pkmod",
      "topics": [
        "update.pkmod"
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    },
    {
      "page": "validate_pkmod",
      "title": "pkmod validation checks",
      "topics": [
        "validate_pkmod"
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    },
    {
      "page": "validate_poppkmod",
      "title": "Perform validation checks on a `poppkmod` object",
      "topics": [
        "validate_poppkmod"
      ]
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